St. Therese Parish, located in Southgate, Kentucky, was canonically established on August 15, 1927, under the leadership of Bishop Francis W. Howard. The parish was formed from portions of the parishes of St. Thomas (Fort Thomas), St. Vincent de Paul (Clifton), and St. Francis de Sales (Cote Brilliante). Reverend F. Borgias Lehr was appointed the first pastor. The parish's name honored St. Therese of the Child Jesus, the "Little Flower," who had recently been canonized in 1925.

The first property acquired for the parish, formerly part of the Wiedemann Brewery interests, included a building known as the Old Heidelberg. This structure was promptly remodeled to serve as both a place of worship and a three-room school. The initial Mass was celebrated on August 21, 1927, in the rear wing of the building, which had previously housed bowling alleys. By October 2, 1927, Bishop Howard dedicated the combined church and school, which opened with an enrollment of 74 pupils under the care of the Benedictine Sisters.

From its inception, the parish rapidly grew in both spirit and size. Monsignor Lehr worked tirelessly to establish parish organizations that would strengthen community bonds and foster spiritual growth. By 1936, the school expanded to accommodate increasing enrollment, adding two classrooms. In 1937, the parish welcomed its first assistant pastor, Reverend John Schuler, as the community continued to flourish.

In the mid-20th century, significant developments included the acquisition of a rectory in 1944 and the burning of the parish mortgage in 1947, marking 20 years of progress. Monsignor Lehr’s dedication to the parish was unwavering until his passing in 1957.

Under Father Paul J. Brinker, who succeeded Monsignor Lehr in 1957, St. Therese Parish embarked on a new era of growth. Recognizing the need for modern facilities, the parish undertook ambitious construction projects. A new school and convent were built in 1952 and were dedicated by Bishop William T. Mulloy. The old school was razed, and a new front was built for the church. On February 5, 1957, Monsignor Lehr passed away after 30 years as Pastor of St. Therese.

In 1963, a new church and rectory were built, with the church accommodating 650 parishioners. After its completion, additional classrooms were constructed in the church undercroft. On June 7, 1964, Bishop Richard Ackerman dedicated the new church, which remains a central feature of the parish. Designed with modern architectural elements, the church also honors traditional liturgical design.

In 1992, another major construction project was completed, resulting in the addition of a new gym and multi-purpose facility. The gym quickly became the heart of after-school extracurricular activities, hosting numerous sporting events, school gatherings, and community programs. It is home to the long-running Mustang Classic Basketball Tournament, a tradition that has been a highlight for students for decades, bringing together students, families, and alumni in a celebration of athleticism and school spirit. 

In 1998, five classrooms, a computer lab, a school kitchen expansion, a new library, and additional storage space were added to the parish school. The library has since become the heart of the school, supporting its strong emphasis on reading and literacy. It serves as a dedicated space where students can explore a diverse selection of books, fostering a love for reading and helping them discover literature suited to their individual interests and reading levels.

As St. Therese Parish approached its 50th anniversary in 1977, its legacy was celebrated with pride. From its humble beginnings in a repurposed inn to becoming a vibrant diocesan shrine, the parish exemplifies dedication, resilience, and faith. The intercession of St. Therese and the tireless efforts of clergy, religious, and laity have built a lasting spiritual home for generations of Catholics in Southgate.

As St. Therese Parish approaches its 100th anniversary in 2027, the community reflects on its rich history while looking forward to the future with hope and determination. Plans are underway to celebrate this significant milestone, honoring the legacy of past generations while embracing new opportunities to grow in faith and service. The parish remains committed to fostering a welcoming and vibrant environment for worship, education, and community engagement, ensuring that St. Therese Parish continues to be a beacon of light and faith for future generations.

In 2019, a project to refurbish our church was begun. New paint and updated lighting now grace our worship space. A renovated sanctuary area completed the project which includes an access ramp and railings for the steps to assist those with mobility issues. The beautiful new wood and marble panel on the rear sanctuary wall highlights the crucifix and tabernacle. Our beautiful church continues to be the center of our worship and parish life!

Increased school enrollment and changes in educational programs created the need for additional classrooms. In the summer of 2025, the former undercroft area and nearby space was renovated and refurbished into four beautiful classrooms. Since its founding in 1927, our parish has supported and valued the ministry of Catholic education through our Catholic school. These functional new spaces now assist us in this continuous educational ministry.